Human IL-4 R alpha / CD124 Protein, Fc Tag

Source : 

Human IL-4 R alpha, Fc Tag (ILR-H5253) is expressed from human 293 cells (HEK293). It contains AA Met 26 - His 232 (Accession # P24394-1).

 

Molecule : IL-4 R alpha

 

Synonyms : IL4R,CD124,IL4RA

 

Format : Powder

 

Category : Bio-Markers & CD Antigens

 

Accession : NP_000409.1

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 50.4 kDa

 

Characteristics :

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 50.4 kDa. The protein migrates as 60-80 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : Tris with Glycine, Arginine and NaCl, pH7.5

 

Description :

IL-4 R alpha is also known as IL4R, CD124, IL-4RA.This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE antibody production in B cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitis, asthma, or eczema. The binding of IL-4 or IL-13 to the IL-4 receptor on the surface of macrophages results in the alternative activation of those macrophages. Interleukin-4 receptor has been shown to interact with SHC1.

 

References :

(1)Tundup S., 2012, Ann. N. Y. Acad. Sci., 1253: E1–E13.
(2)Ikizawa K, Yanagihara Y., 2000, Biochem. Biophys. Res. Commun., 268 (1): 54–9.
(3)Kashiwada M., 2001, J. Immunol., 167 (11): 6382–7.