Human IL-37 / IL-1F7b Protein, His Tag

Source : 

Human IL-37, His Tag (ILB-H5141) is expressed from E.coli cells. It contains AA Val 46 - Asp 218 (Accession # AAH20637.1).

 

Molecule : IL-37

 

Synonyms : IL1F7,IL37,FIL1Z,IL1H4,IL1RP1

 

Format : Powder

 

Category : Cytokines&Growth Factors

 

Accession : AAH20637.1

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 20.3 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 20.3 kDa. The protein migrates as 20.3 kDa under reducing (R) condition (SDS-PAGE).

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : PBS, pH7.4

 

Description :

Interleukin-1 family member 7 (IL1F7b) ,a member of the IL-1 family, is aslo known as interleukin-37, interleukin-1 homolog 4 (IL-1H4), interleukin-1 zeta (IL-1 zeta) and interleukin-1-related protein, which can interact with SMAD3 and bind to IL18R1, but not to IL1R1, with lower affinity than IL18. IL1F7b is a suppressor of innate inflammatory and immune responses involved in curbing excessive inflammation. This function requires SMAD3. Therefore,IL1F7b can suppress, or reduce, proinflammatory cytokine production, including IL1A and IL6, as well as CCL12, CSF1, CSF2, CXCL13, IL1B, IL23A and IL1RN, but spare anti-inflammatory cytokines. Furthermore,IL1F7b can also inhibit dendritic cell activation.

 

References :

(1) Pan G., et al., 2001, Cytokine 13:1-7.
(2) Sharma S., et al., 2008, J. Immunol. 180:5477-5482.
(3) Nold M.F., et al., 2010, Nat. Immunol. 11:1014-1022.