Human IL-31 RA Protein, Fc Tag

Source : 

Human IL-31 RA, Fc Tag (ILA-H5256) is expressed from human 293 cells (HEK293). It contains AA Ala 20 - Glu 519 (Accession # Q8NI17-1).

 

Molecule : IL-31 RA

 

Synonyms : IL-31 RA,IL-31RA,hGLM-R,CRL3,GPL,ZcytoR17,GLM-R,IL-31R-alpha,Gp130-like receptor

 

Format : Powder

 

Category : Bio-Markers & CD Antigens

 

Accession : XP_011541444.1

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 83.5 kDa

 

Characteristics :

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 83.5 kDa. The protein migrates as 105-115 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : Tris with Glycine, Arginine and NaCl, pH7.5

 

Description :

Interleukin-31 receptor subunit alpha is a protein that in humans is encoded by the IL31RA gene, also known as IL-31 receptor subunit alpha, IL-31RA, GLM-R, Gp130-like receptor, CRL3, GPL. Oncostatin M receptor (OSMR) and IL31RA form the heterodimeric receptor through which IL31 signals. IL31RA is a strong activator of STAT3 and STAT5, whereas STAT1 is only marginally tyrosine-phosphorylated. dditionally, demonstrate Jak1 binding to GPL and its activation in heteromeric complexes with the OSMRbeta but also in a homomeric receptor complex.

 

References :

(1) Dillon SR. Nat Immunol. 2004 Jul;5(7):752-60.
(2) Ghilardi N. J Biol Chem. 2002 May 10;277(19):16831-6.
(3) Dreuw A. J Biol Chem. 2004 Aug 20;279(34):36112-20.