Human IL-27 Ra / TCCR Protein, Fc Tag

Source : 

Human IL-27 Ra, Fc Tag (ILA-H5254) is expressed from human 293 cells (HEK293). It contains AA Gln 33 - Arg 514 (Accession # AAH28003).

 

Molecule : IL-27 Ra

 

Synonyms : IL27RA,CRL1,TCCR,WSX1

 

Format : Powder

 

Category : Bio-Markers & CD Antigens

 

Accession : AAH28003

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 78.9 kDa

 

Characteristics :

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 78.9 kDa. The protein migrates as 100-116 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : Tris with Glycine, Arginine and NaCl, pH7.5

 

Description :

Interleukin-27 receptor subunit alpha ( IL27RA) is also known as Cytokine receptor WSX-1, Cytokine receptor-like 1, Type I T-cell cytokine receptor (TCCR), ZcytoR1, IL27RA belongs to the type I cytokine receptor family and type 2 subfamily. IL27RA contains three fibronectin type-III domains. IL27RA is highly expressed in lymphoid tissues such as spleen, lymph nodes and peripheral blood leukocytes. IL27RA is receptor for IL27, but requires IL6ST/gp130 to mediate signal transduction in response to IL27. IL27RA involved in the regulation of Th1-type immune responses. IL27RA also appears to be involved in innate defense mechanisms.

 

References :

(1) Sprecher C.A., et al., 1998, Biochem. Biophys. Res. Commun. 246:82-90.
(2) Chen Q., et al., 2000, Nature 407:916-920.
(3) Pflanz S., et al., 2004, J. Immunol. 172:2225-2231.