Human IL-22 Protein, His Tag

Source : 

Human IL-22, His Tag (IL2-H524a) is expressed from human 293 cells (HEK293). It contains AA Ala 34 - Ile 179 (Accession # Q9GZX6-1).

 

Molecule : IL-22

 

Synonyms : IL-22,IL-TIF,ZCYTO18

 

Format : Powder

 

Category : Cytokines&Growth Factors

 

Accession : NP_065386.1

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 18.6 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 18.6 kDa. The protein migrates as 28-34 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : PBS, pH7.4

 

Description :

Interleukin-22 (IL22) is also known as cytokine Zcyto18, IL-10-related T-cell-derived-inducible factor (IL-TIF), which is belongs to the IL-10 family or IL-10 superfamily (including IL-19, IL-20, IL-24, and IL-26), a class of potent mediators of cellular inflammatory responses. IL-22 is produced by activated DC and T cells and initiates innate immune responses against bacterial pathogens especially in epithelial cells such as respiratory and gut epithelial cells. IL-22 biological activity is initiated by binding to a cell-surface complex composed of IL-22R1 and IL-10R2 receptor chains and further regulated by interactions with a soluble binding protein IL-22BP. IL-22 also promotes hepatocyte survival in the liver and epithelial cells in the lung and gut similar to IL-10.

 

References :

(1) Pestka S., et al., 2004, Annu. Rev. Immunol. 22: 929–79.
(2) Witte K., et al., 2010, Cytokine Growth Factor Rev 21 (4): 237–51.
(3) Moore KW., et al., 2001, Annu. Rev. Immunol. 19: 683–765.