Human IL-21 R Protein, Fc Tag

Source : 

Human IL-21 R, Fc Tag (ILR-H5257) is expressed from human 293 cells (HEK293). It contains AA Cys 20 - Pro 236 (Accession # AAH04348).

 

Molecule : IL-21 R

 

Synonyms : IL21R,CD360,NILR

 

Format : Powder

 

Category : Bio-Markers & CD Antigens

 

Accession : AAH04348

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 51.6 kDa

 

Characteristics :

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 51.6 kDa. As a result of glycosylation, the protein migrates as 60-70 kDa under reducing (R) condition, and 120-130 kDa under non-reducing (NR) condition (SDS-P

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : 50 mM Tris, 100 mM Glycine, pH7.5

 

Description :

Interleukin-21 receptor (IL21R) is also known as CD antigen CD360, Novel interleukin receptor (NILR), is a receptor for interleukin-21 and belongs to the type I cytokine receptor family or type 4 subfamily. IL21R contains two fibronectin type-III domains. IL21R is selectively expressed in lymphoid tissues and most highly expressed in thymus and spleen. IL21R transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells.

 

References :

(1) Hamming O.J., et al., 2012, J. Biol. Chem. 287:9454-9460.
(2) Kotlarz D., et al., 2013, J. Exp. Med. 210:433-443.