Human IL-2 R beta / CD122 Protein, Fc Tag (SPR verified)

Source : 

Human IL-2 R beta, Fc Tag (SPR verified) (ILB-H5253) is expressed from human 293 cells (HEK293). It contains AA Ala 27 - Asp 239 (Accession # NP_000869.1).

 

Molecule : IL-2 R beta

 

Synonyms : IL2RB,RP5-1170K4.6,CD122,P70-75

 

Format : Powder

 

Category : Bio-Markers & CD Antigens

 

Accession : NP_000869.1

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 50.7 kDa

 

Characteristics :

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 50.7 kDa. The protein migrates as 62-70 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : 50 mM Tris, 100 mM Glycine, pH7.5

 

Description :

Interleukin-2 receptor subunit beta (IL2RB) is also known as CD122, which Belongs to the type I cytokine receptor family. Type 4 subfamily. IL2RB contains 1 fibronectin type-III domain. IL2RB / CD122 is involved in T cell-mediated immune responses, is present in 3 forms with respect to ability to bind interleukin 2. The low affinity form is a monomer of the alpha subunit and is not involved in signal transduction. The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high affinity forms of the receptor are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2.

 

References :

(1) Mulloy J.C., et al., 1996, J. Virol. 70:3599-3605.
(2) Lindholm C.K., 2002, Biochem. Biophys. Res. Commun. 296:929-936.