Human IL-1RL1 / ST2 Protein, Fc Tag

Source : 

Human IL-1RL1, Fc Tag (IL1-H5250) is expressed from human 293 cells (HEK293). It contains AA Lys 19 - Pro 323 (Accession # NP_003847).

 

Molecule : IL-1RL1

 

Synonyms : IL1RL1,DER4,FIT-1,IL33R,ST2,ST2L,ST2V,T1

 

Format : Powder

 

Category : Bio-Markers & CD Antigens

 

Accession : NP_003847

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 61.0 kDa

 

Characteristics :

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 61.0 kDa. The protein migrates as 80-100 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : Tris with Glycine, Arginine and NaCl, pH7.5

 

Description :

Interleukin 1 receptor-like 1 (IL1RL1) is also known as ST2, DER4, FIT-1, IL33R, ST2L, ST2V, which belongs to the interleukin-1 receptor family. IL1RL1 contains three Ig-like C2-type (immunoglobulin-like) domains and one TIR domain. IL1RL1 is receptor for interleukin-33 (IL-33), its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. IL1RL1 possibly involved in helper T-cell function. IL1RL1 can interact with MYD88, IRAK1, IRAK4, and TRAF6.

 

References :

(1) Tago K., et al., 2001, Biochem. Biophys. Res. Commun. 285:1377-1383.
(2) Schmitz J., et al., 2005, Immunity 23:479-490.