Human IL-18BP Protein, His Tag

Source : 

Human IL-18BP, His Tag (ILP-H5222) is expressed from human 293 cells (HEK293). It contains AA Thr 31 - Gly 194 (Accession # NP_001138529).

 

Molecule : IL-18BP

 

Synonyms : IL18BP,IL18BPa,Tadekinig-alfa

 

Format : Powder

 

Category : Bio-Markers & CD Antigens

 

Accession : NP_001138529

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 18.5 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 18.5 kDa. The protein migrates as 32-50 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : PBS, pH7.4

 

Description :

Interleukin-18-binding protein (IL18BP) is also known as Tadekinig-alfa, IL18BPa, which functions as an IL18 inhibitor. IL18BP is a secreted protein which contains one Ig-like C2-type (immunoglobulin-like) domain. IL18BP does not have a transmembrane domain and hence is not anchored to the cell membrane. IL18BP is strongly expressed in heart, lung, placenta and spleen. Isoform A of IL18BP binds to IL-18 and inhibits its activity. IL18BP also functions as an inhibitor of the early TH1 cytokine response. IL18BP suppresses the production of IFN-gamma resulting in reduced T-helper type 1 immune responses.

 

References :

(1) Novick D., et al., 1999, Immunity 10:127-136.
(2) Aizawa Y., et al., 1999, FEBS Lett. 445:338-342.
(3) Halim A., et al., 2011, Mol. Cell. Proteomics 0:0-0.