Human IL-18 R1 / CD218a Protein, Fc Tag

Source : 

Human IL-18 R1, Fc Tag (IL1-H5259) is expressed from human 293 cells (HEK293). It contains AA Ala 19 - Arg 329 (Accession # AAH69575).

 

Molecule : IL-18 R1

 

Synonyms : IL18R1,IL1RRP,CD218a,IL18Ra

 

Format : Powder

 

Category : Bio-Markers & CD Antigens

 

Accession : AAH69575

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 62.4 kDa

 

Characteristics :

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 62.4 kDa. The protein migrates as 90-110 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : Tris with Glycine, Arginine and NaCl, pH7.5

 

Description :

Interleukin-18 receptor 1 (IL18R1) is also known as CD218 antigen-like family member A (CD218a), IL1 receptor-related protein (IL-1Rrp or IL1R-rp), CDw218a, IL18Ra, IL1RRP, which belongs to the interleukin-1 receptor family. IL18R1 contains three Ig-like C2-type (immunoglobulin-like) domains and one TIR domain. IL18R1 is receptor for interleukin 18 (IL-18). IL18R1 binds to the agonist leads to the activation of NF-kappa-B, but does not bind IL1A/interleukin-1 alpha or IL1B/interleukin-1 beta.

 

References :

(1) Parnet P., et al., 1996, J. Biol. Chem. 271:3967-3970.
(2) Torigoe K., et al., 1997, J. Biol. Chem. 272:25737-25742.