Human IL-17 RE (155-454) Protein, Fc Tag

Source : 

Human IL-17 RE (155-454), Fc Tag (ILE-H5256) is expressed from human 293 cells (HEK293). It contains AA Thr 155 - His 454 (Accession # Q8NFR9-1).

 

Molecule : IL-17 RE

 

Synonyms : IL-17 RE,IL17RE,IL-17RE,IL-17 receptor E

 

Format : Powder

 

Category : Bio-Markers & CD Antigens

 

Accession : NP_705613.1

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 60.5 kDa

 

Characteristics :

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 60.5 kDa. The protein migrates as 66-80 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : Tris with Glycine, Arginine and NaCl, pH7.5

 

Description :

Interleukin-17 receptor E (IL-17 RE) is an orphan receptor of the IL-17 receptor family, also known as UNQ3056, PRO9877, IL-17 Receptor E. IL-17RE is known to be expressed in the pancreas, brain, and prostate. IL-17RE is a receptor specific to IL-17C and has an essential role in host mucosal defense against infection. IL-17C functioned in a unique autocrine manner, binding to a receptor complex consisting of the receptors IL-17RA and IL-17RE, which was preferentially expressed on tissue epithelial cells. Some data identify IL-17RE as a receptor of IL-17C that regulates early innate immunity to intestinal pathogens.

 

References :

(1) Song X. Nat Immunol. 2011. 12(12):1151-8.
(2) Ramirez-Carrozzi V. Nat Immunol. 2011. 12(12):1159-66.
(3) Pfeifer P. Am J Respir Cell Mol Biol. 2013. 48(4):415-21.