Human IL-17 RC Protein, Fc Tag (MALS verified)

Source : 

Human IL-17 RC, Fc Tag (ILC-H5255) is expressed from human 293 cells (HEK293). It contains AA Leu 21 - Arg 467 (Accession # NP_703190.2).

 

Molecule : IL-17 RC

 

Synonyms : IL-17 RC,IL-17RC,IL17Rhom,IL-17 receptor C,IL-17RL,ZcytoR14

 

Format : Powder

 

Category : Bio-Markers & CD Antigens

 

Accession : NP_703190.2

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 76.2 kDa

 

Characteristics :

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 76.2 kDa. The protein migrates as 85-115 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : PBS, pH7.4

 

Description :

Interleukin-17 receptor C (IL-17 RC), also known as IL17Rhom, IL-17RL, is the receptor for IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RA. IL-17A activity is inhibited by IL-17RA, IL-17F is inhibited by IL-17RC, and a combination of soluble IL-17RA/IL-17RC receptors is required for inhibition of the IL-17F/IL-17A activity. Furthermore, activation of IL17RC can lead to the induction of expression of inflammatory chemokines and cytokines such as CXCL1.

 

References :

(1) Wright JF. J Immunol. 2008 Aug 15;181(4):2799-805.
(2) Toy D. J Immunol. 2006 Jul 1;177(1):36-9.
(3) Kuestner RE. J Immunol. 2007 Oct 15;179(8):5462-73.