Human IL-17 RA / CD217 Protein, His Tag

Source : 

Human IL-17 RA, His Tag (ILA-H5222) is expressed from human 293 cells (HEK293). It contains AA Leu 33 - Trp 320 (Accession # Q96F46-1).

 

Molecule : IL-17 RA

 

Synonyms : CD217,CDw217,IL-17RA,IL17R,CANDF5,hIL-17R

 

Format : Powder

 

Category : Bio-Markers & CD Antigens

 

Accession : NP_055154.3

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 34.3 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 34.3 kDa. The protein migrates as 50-65 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : PBS, pH7.4

 

Description :

Interleukin 17 receptor A (IL17RA) is also known as cluster of differentiation w217 (CDw217), is a pro-inflammatory cytokine secreted by activated T-lymphocytes, belong to ubiquitous type I membrane glycoprotein, and binds with low affinity to interleukin 17A (IL17A). IL 17R mRNA exhibits a broad tissue distribution, and has been detected in virtually all cells and tissues tested . IL 17RA associates with IL 17RC to form a signaling receptor complex for IL 17 and IL 17F . Ligand and IL 17RA ligation promotes T cell activation and the production of IL - 6, G-CSF, SCF, and multiple pro-inflammatory chemokines. Defects in IL17RA are the cause of familial candidiasis type 5 (CANDF5).

 

References :

(1) Puel A., et al., 2011, Science, 332:65-68.
(2) Ely L.K., et al., 2009, Nat. Immunol, 10: 1245-1251.
(3) Yao Z. et al., 1997, Cytokine, 9 (11): 794-800.