Human IL-15 R alpha / CD215 Protein, Fc Tag

Source : 

Human IL-15 R alpha, Fc Tag (ILA-H5253) is expressed from human 293 cells (HEK293). It contains AA Ile 31 - Thr 205 (Accession # Q13261-1).

 

Molecule : IL-15 R alpha

 

Synonyms : IL-15 R alpha,CD215,IL15RA,IL-15RA,IL-15R-alpha

 

Format : Powder

 

Category : Cytokines&Growth Factors

 

Accession : NP_002180.1

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 44.8 kDa

 

Characteristics :

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 44.8 kDa. The protein migrates as 60-80 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : Tris with Glycine, Arginine and NaCl, pH7.5

 

Description :

IL15R is a heterotrimer of IL15RA, IL2RB and IL2RG. IL-15RA, also known as CD215, IL-15 R alpha, is a widely expressed 60 kDa transmembrane glycoprotein. High-affinity receptor for interleukin-15. Can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells. Expression of different isoforms may alter or interfere with signal transduction. An interleukin (IL)-15 superagonist/IL-15 receptor α fusion complex (IL-15SA/IL-15RA; ALT-803) activates the IL-15 receptor on CD8 T cells and NK cells, and has shown significant anti-tumor. Signal transduction involves SYK. Higher levels of soluble sIL-15RA form in comparison with membrane-bound forms is present in all brain structures.

 

References :

(1) Fujii R. 2018. Cancer Immunol Immunother. 67(4):675-689.
(2) Bulanova E. 2001. J Immunol. 167(11):6292-302.
(3) Chirifu M. 2007. Nat Immunol. 8(9):1001-7.