Human IL-12 R beta 1 / CD212 Protein, His Tag

Source : 

Human IL-12 R beta 1, His Tag (ILB-H52H9) is expressed from human 293 cells (HEK293). It contains AA Cys 24 - Glu 540 (Accession # P42701-1).

 

Molecule : IL-12 R beta 1

 

Synonyms : IL-12 R beta 1,IL12RB1,CD212,IL12R,IL12RB,IL-12RB1

 

Format : Powder

 

Category : Bio-Markers & CD Antigens

 

Accession : NP_005526.1

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 59.0 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 59.0 kDa. The protein migrates as 66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : PBS, pH7.4

 

Description :

The human IL-12 R subunit is a member of the cytokine receptor superfamily and the functional high-affinity IL-12R is composed of at least two beta-type cytokine receptor subunits, each independently exhibiting a low affinity for IL-12. IL-12 R beta 1 (Interleukin-12 receptor subunit beta-1) is also known as IL-12RB1, CD212. Functions as an interleukin receptor which binds interleukin-12 with low affinity and is involved in IL12 transduction. Associated with IL12RB2 it forms a functional, high affinity receptor for IL12. Associates also with IL23R to form the interleukin-23 receptor which functions in IL23 signal transduction probably through activation of the Jak-Stat signaling cascade.

 

References :

(1) Presky DH, et al. 1996. Proc Natl Acad Sci U S A. 93(24):14002-7.
(2) Parham C, rt al. 2002. J Immunol. 168(11):5699-708.
(3) Reeme AE, et al. 2018. Genes Immun. doi: 10.1038/s41435-018-0023-2.