Human IL-1 Rrp2 / IL-1 R6 Protein, His Tag

The Interleukin 1 receptor family (IL-1 R) comprises at least eleven members including IL-1?RI (IL-1 R1), IL-1?RII (IL-1?R2), IL-1?RAcP (IL?1?R3), ST2 (T1/IL-1?R4), IL-18?Ra (IL-1?Rrp/IL-1?R5), IL-1?Rrp2 (IL-1?RL2/IL-1?R6), IL-18?Rb (AcPL/IL-1?R7), IL-1RAPL?1 (TIGIRR?2/IL?1?R8), and TIGIRR-1 (IL-1?R9). All family members possess three immunoglobulin (Ig)-like domains in their extracellular region. Most members also have an intracellular TIR (Toll-like receptor/IL-1 receptor signaling) domain that is also conserved in the Toll-like receptor family. Related proteins, SIGIRR (single Ig domain-containing IL-1 R-related molecule) and IL-18BP, differ from the other members by having only one Ig domain.