Human IL-1 RII / CD121b Protein, His Tag

Source : 

Human IL-1 RII, His Tag (IL2-H4226) is expressed from human 293 cells (HEK293). It contains AA Phe 14 - Glu 343 (Accession # NP_004624.1).

 

Molecule : IL-1 RII

 

Synonyms : CD121b,IL1RB,IL1R2,CDw121b

 

Format : Powder

 

Category : Bio-Markers & CD Antigens

 

Accession : NP_004624.1

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 38.9 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 38.9 kDa. The protein migrates as 50-60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : PBS, pH7.4

 

Description :

Interleukin-1 receptor type 2 (IL1R2) is also known as CD121 antigen-like family member B (CDw121b), IL-1 type II receptor, Interleukin-1 receptor type II, belongs to the interleukin-1 receptor family. Two distinct types of IL1 receptors which are able to bind IL1 specifically have been identified, designated as IL1RI (IL1RA) and IL1RII (IL1RB). IL1R2 is non-signaling receptor for IL1A, IL1B and IL1RN, reduces IL1B activities. Serves as a decoy receptor by competetive binding to IL1B and preventing its binding to IL1R1. IL1R2 modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors.

 

References :

(1) Liu C., et al., 1996, J. Biol. Chem. 271:20965-20972.
(2) Giri J.G., et al., 1994, J. Immunol. 153:5802-5809.
(3) Symons J.A., et al., 1995, Proc. Natl. Acad. Sci. U.S.A. 92:1714-1718.
(4) Orlando S., et al., 1997, J. Biol. Chem. 272:31764-31769.
(5) Wang D., et al., 2010, Nat. Immunol. 11:905-911.