Human IGFBP-7 Protein, His Tag

Source : 

Human IGFBP-7, His Tag (IG7-H5240) is expressed from human 293 cells (HEK293). It contains AA Asp 30 - Leu 282 (Accession # NP_001544).

 

Molecule : IGFBP-7

 

Synonyms : IBP7,IGFBP7

 

Format : Powder

 

Category : Bio-Markers & CD Antigens

 

Accession : NP_001544

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 27.0 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 27.0 kDa. The protein migrates as 35 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : PBS, pH7.4

 

Description :

Insulin-like growth factor-binding protein 7 (IGFBP7) is also known as IGFBP-rP1, MAC25 protein, PGI2-stimulating factor, prostacyclin-stimulating factor and tumor-derived adhesion factor, which contains one Ig-like C2-type (immunoglobulin-like) domain, one IGFBP N-terminal domain and one Kazal-like domain. The major function of IGFBP7 is the regulation of availability of insulin-like growth factors (IGFs) in tissue as well as in modulating IGF binding to its receptors. IGFBP7 binds to IGF with high affinity except for IGF-I and IGF-II.IGFBP7 also stimulates cell adhesion. Furthermore, IGFBP7 is implicated in some cancers.

 

References :

(1) Yamauchi T., et al., 1994, Biochem. J. 303:591-598.
(2) Oh Y., et al., 1996, J. Biol. Chem. 271:30322-30325.
(3) Wilson E.M., et al., 2001, J. Clin. Endocrinol. Metab. 86:4504-4511.