Human IGFBP-4 Protein, His Tag

Source : 

Human IGFBP-4, His Tag (IG4-H52E4) is expressed from human 293 cells (HEK293). It contains AA Asp 22 - Glu 258 (Accession # P22692-1).

 

Molecule : IGFBP-4

 

Synonyms : IGFBP4,IBP-4

 

Format : Powder

 

Category : Bio-Markers & CD Antigens

 

Accession : NP_001543.2

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 27.9 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 27.9 kDa. The protein migrates as 33-37 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : PBS, pH7.4

 

Description :

Insulin-like growth factor-binding protein 4 (IGFBP-4) is also known as IGF-binding protein 4, which contains an IGFBP domain and a thyroglobulin type-I domain. IGFBP-4 binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma in both glycosylated and non-glycosylated forms. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. IGFBP-4 is a unique protein and it consistently inhibits several cancer cells in vivo and in vitro. Its inhibitory action has been shown in vivo in prostate and colon. IGFBP-4 is secreted by all colon cancer cells.

 

References :

(1) Tagliabracci V.S., et al., 2015, Cell 161:1619-1632.
(2) Culouscou J.M., et al.,1991, Cancer Res. 51:2813-2819.