Human IFN-alpha / beta R2 Protein, Fc Tag

Source : 

Human IFNAR2, Fc Tag (IF2-H5255) is expressed from human 293 cells (HEK293). It contains AA Ile 27 - Lys 243 (Accession # P48551-2).

 

Molecule : IFN-alpha/beta R2

 

Synonyms : IFNAR2,IFNARB,IFNABR,IFN-R-2,IFN-alpha/beta receptor 2

 

Format : Powder

 

Category : Bio-Markers & CD Antigens

 

Accession : NP_997467.1

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 51.4 kDa

 

Characteristics :

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 51.4 kDa. The protein migrates as 66-90 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : Tris with Glycine, Arginine and NaCl, pH7.5

 

Description :

Interferon alpha/beta receptor 2 (IFNAR2) is also known as IFN-alpha binding protein, IFN-alpha/beta receptor 2, Type I interferon receptor 2, IFNABR and IFNARB, which is a single-pass type I membrane protein and belongs to the type II cytokine receptor family. IFNAR2 can associate with IFNAR1 to form the type I interferon receptor. IFNAR2 is a receptor for interferons alpha and beta.IFNAR2 involves in IFN-mediated STAT1, STAT2 and STAT3 activation. Isoform 1 and isoform 2 of IFNAR2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1. Isoform 3 of IFNAR2 is a potent inhibitor of type I IFN receptor activity.Genetic variations in IFNAR2 influence susceptibility to hepatitis B virus (HBV) infection.

 

References :

(1) Novick D., et al., 1994, Cell 77:391-400. (2) Novick D., et al., 1995, J. Leukoc. Biol. 57:712-718. (3) Li X., et al., 1997, Mol. Cell. Biol. 17:2048-2056.