Human IFN-alpha / beta R1 Protein, Fc Tag

Source : 

Human IFNAR1, Fc Tag (IF1-H5253) is expressed from human 293 cells (HEK293). It contains AA Lys 28 - Lys 436 (Accession # NP_000620).

 

Molecule : IFN-alpha/beta R1

 

Synonyms : IFNAR1,IFNAR,CRF2-1,IFN-R-1,IFNAR-1

 

Format : Powder

 

Category : Bio-Markers & CD Antigens

 

Accession : NP_000620

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 73.8 kDa

 

Characteristics :

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 73.8 kDa. The protein migrates as 100-130 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : Tris with Glycine, Arginine and NaCl, pH7.5

 

Description :

Interferon alpha/beta receptor 1 ( IFNAR1) is also known as Cytokine receptor class-II member 1, Cytokine receptor family 2 member 1 (CRF2-1), Type I interferon receptor 1, IFNAR, which belongs to the type II cytokine receptor family. IFNAR1 /IFNAR contains four fibronectin type-III domains. IFNAR1 associates with IFNAR2 to form the type I interferon receptor. IFNAR1 is receptor for interferons alpha and beta. IFNAR1 can transduce IFNB signals without the help of IFNAR2, and not activating the Jak-STAT pathway.

 

References :

(1) Colamonici O., et al., 1994, Mol. Cell. Biol. 14:8133-8142.
(2) Li X., et al., 1997, Mol. Cell. Biol. 17:2048-2056.
(3) Russell-Harde D., et al., 1999, Biochem. Biophys. Res. Commun. 255:539-544.