Human ICOS / CD278 (C136S, C137S) Protein, His Tag

Source : 

Human ICOS (C136S, C137S), His Tag (ICS-H52H6) is expressed from human 293 cells (HEK293). It contains AA Glu 21 - Phe 141 (Accession # Q9Y6W8-1 (C136S, C137S)).

 

Molecule : ICOS

 

Synonyms : ICOS,CD278,AILIM,Inducible T-cell costimulator

 

Format : Powder

 

Category : Immune Checkpoint Proteins

 

Accession : NP_036224.1 (C136S, C137S)

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 15.2 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 15.2 kDa. The protein migrates as 23-30 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : PBS, pH7.4

 

Description :

Inducible T-cell costimulator (ICOS) is also known as Activation-inducible lymphocyte immunomediatory molecule (AILIM), CD278, which belongs to the CD28 family of immune costimulatory receptors consisting of CD28, CTLA-4 and PD-1. ICOS enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. CD278 / ICOS prevents the apoptosis of pre-activated T-cells and also plays a critical role in CD40-mediated class switching of immunoglobin isotypes.

 

References :

(1) Hutloff A., et al., 1999, Nature 397:263-266.
(2) Tezuka K., et al., 2000, Biochem. Biophys. Res. Commun. 276:335-345.
(3) Beier K.C., et al., 2000, Eur. J. Immunol. 30:3707-3717.