Human Iba1 / AIF-1 Protein, His Tag

Source : 

Human Iba1, His Tag (IB1-H51H9) is expressed from E.coli cells. It contains AA Met 1 - Pro 147 (Accession # P55008-1).

 

Molecule : Iba1

 

Synonyms : Iba1,AIF-1,AIF1,G1,IBA1,LCP1

 

Format : Powder

 

Category : Other Recombinant Proteins

 

Accession : NP_001614.3

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 18.6 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 18.6 kDa. The protein migrates as 18-20 kDa under reducing (R) condition (SDS-PAGE).

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : PBS, pH7.4

 

Description :

Allograft inflammatory factor 1 (AIF1), also known as IBA1, daintain and Protein G1, is an actin-binding protein. Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation.

 

References :

(1) Chen X, et al. 2004. Arterioscler Thromb Vasc Biol. 24(7):1217-22.
(2) Kelemen SE, et al. 2005. Am J Pathol. 167(2):619-26.
(3) Schulze JO, et al. 2008. FEBS J. 275(18):4627-40.