Human HVEM / TNFRSF14 Protein, Strep Tag

Source : 

Human HVEM, Strep Tag (HVM-H5283) is expressed from human 293 cells (HEK293). It contains AA Leu 39 - Val 202 (Accession # NP_003811.2).

 

Molecule : HVEM

 

Synonyms : TNFRSF14,ATAR,HVEA,HVEM,LIGHTR,TR2,CD270

 

Format : Powder

 

Category : Immune Checkpoint Proteins

 

Accession : NP_003811.2

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 20.4 kDa

 

Characteristics :

This protein carries a twin strep tag at the C-terminus. The protein has a calculated MW of 20.4 kDa. The protein migrates as 27-50 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : PBS, pH7.4

 

Description :

Herpesvirus entry mediator (HVEM) is also known as TNFRSF14, TR2 (TNF receptorlike molecule) and ATAR (another TRAF associated receptor), is a type I membrane protein belonging to the TNF/NGF receptor superfamily. HVEM expression has been detected in peripheral blood T cells, B cells, monocytes and in various tissues enriched in lymphoid cells. The extracellular domain of HVEM has been shown to interact directly with the herpes simplex virus envelope glycoprotein D (gD). Two TNF superfamily ligands, including the secreted TNFβ (lymphotoxin α) and the membrane protein LIGHT (lymphotoxins, exhibits inducible expression, and competes with HSV glycoprotein D for HVEM, a receptor expressed by T lymphocytes), have been shown to be the cellular ligands for HVEM. Besides HVEM, LIGHT can also interact with LTβR, the receptor for lymphotoxin αβ heterotrimer. The role of the HVEM LIGHT /LTβ receptor ligand pair in immune function and herpesvirus pathobiology remains to be elucidated.

 

References :

(1) Hsu, H. et al., 1997, J. Biol. Chem. 272:13471.
(2) Mauri, D.N. et al., 1998, Immunity 8:21.
(3) Montgomery, R.I. et al., 1996, Cell 87:427.
(4) Cheung,T.C.et al., 2005, Proc.Natl.Acad.Sci.USA102:13218-23.