Human HSP90AA1 / HSP86 Protein, GST Tag

Source : 

Human HSP90AA1, GST Tag (HS1-H513x) is expressed from E.coli cells. It contains AA Glu 535 - Asp 732 (Accession # NP_005339).

 

Molecule : HSP90AA1

 

Synonyms : HSP90AA1,HSP90A,HSP 86,HSP86,HSPC1,HSPCA,EL52,HSP89A,HSP90N,HSPCAL1,HSPCAL4,HSPN,Hsp89,Hsp90,LAP2

 

Format : Powder

 

Category : Bio-Markers & CD Antigens

 

Accession : NP_005339

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 49.3 kDa

 

Characteristics :

This protein carries a GST tag at the N-terminus. The protein has a calculated MW of 49.3 kDa. The protein migrates as 49 kDa under reducing (R) condition (SDS-PAGE).

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : 50 mM HEPES, 150 mM NaCl, pH7.0

 

Description :

Heat shock protein HSP 90-alpha (HSP90AA1 or HSP90A) is also known as Heat shock 86 kDa (HSP 86 or HSP86), Renal carcinoma antigen NY-REN-38, HSPC1, HSPCA, EL52, HSP89A, HSP90N, HSPCAL1, HSPCAL4, HSPN, Hsp89, Hsp90, LAP2, which belongs to the heat shock protein 90 family. HSP90AA1 undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. HSP90AA1 interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.

 

References :

(1) Martinez-Ruiz A., et al., 2005, Proc. Natl. Acad. Sci. U.S.A. 102:8525-8530.
(2) Forsythe H.L., et al., 2001, J. Biol. Chem. 276:15571-15574.
(3) Yang J., et al., 2005, EMBO J. 24:1-10.