Human HER2 / ErbB2 Protein (Fc Tag)

Species : Human

Synonyms : CD340,ENV,ENVW,ERVWE1,HER-2,HER-2/neu,HER2,HERV-7q,HERV-W-ENV,HERV7Q,HERVW,HERVWENV,MLN 19,MLN19,NEU,NGL,TKR1

Host : HEK293 Cells

Purity :> 90 % as determined by SDS-PAGE

Activity : 1. Measured by its binding ability in a functional ELISA.
Immobilized human ErbB2 at 2.5 £gg/ml can bind Herceptin with a linear range of 3.2-80 ng/ml.
2. Measured by its ability to block anti-ErbB2 mediated inhibition of BT474 human breast ductal carcinoma cell proliferation. The ED₅₀ for this effect is 0.5-3 £gg/mL in the presence of 0.6 ?g/mL Anti-ErbB2/Her2 Monoclonal Antibody.