Human HE4 / WFDC2 Protein, His Tag

Source : 

Human HE4, His Tag (HE4-H5223) is expressed from human 293 cells (HEK293). It contains AA Glu 31 - Phe 124 (Accession # AAH46106).

 

Molecule : HE4

 

Synonyms : HE4,WAP5,WFDC2,EDDM4

 

Format : Powder

 

Category : Bio-Markers & CD Antigens

 

Accession : AAH46106

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 10.9 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 10.9 kDa. The protein migrates as 19 kDa and 22-26 kDa under reducing (R) condition (SDS-PAGE) due to different glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : PBS, pH7.4

 

Description :

Human Epididymis Protein 4 (HE4) is also known as WAP four-disulfide core domain protein 2 (WFDC2), Epididymal secretory protein E4, Major epididymis-specific protein E4, Putative protease inhibitor WAP5, is a member of the WFDC domain family. HE4 / WFDC2 is expressed in pulmonary epithelial cells, and was also found to be expressed in some ovarian cancers. The WFDC domain, or WAP Signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many family members. HE4 is also a small secretory protein, which may be involved in sperm maturation.

 

References :

(1) Hellström, Ingegerd, et al., 2003, Cancer Research 63 (13): 3695–3700.
(2) Kirchhoff C., et al., 1992, Biol Reprod 45 (2): 350–7.
(3) Schummer M., et al., 1999, Gene 238 (2): 375–85.