Human GPA33 / A33 Protein, His Tag

Source : 

Human GPA33, His Tag (GP3-H5224) is expressed from human 293 cells (HEK293). It contains AA Ile 22 - Val 235 (Accession # AAH74830).

 

Molecule : GPA33

 

Synonyms : GPA33,A33

 

Format : Powder

 

Category : Bio-Markers & CD Antigens

 

Accession : AAH74830

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 24.4 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 24.4 kDa. The protein migrates as 33-35 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : PBS, pH7.4

 

Description :

Glycoprotein A33 (GPA33) is also known as Cell surface A33 antigen, is a single-pass type I membrane protein which is expressed in normal gastrointestinal epithelium and in 95% of colon cancers. GPA33 The predicted mature protein has a 213-amino acid extracellular region, a single transmembrane domain, and a 62-amino acid intracellular tail. The sequence of the extracellular region contains 1 Ig-like C2-type (immunoglobulin-like) domain and 1 Ig-like V-type (immunoglobulin-like) domain characteristic of the CD2 subgroup of the immunoglobulin (Ig) superfamily, which contains. GPA33 may play a role in cell-cell recognition and signaling.

 

References :

(1) Heath JK., et al., 1997, Proc Natl Acad Sci U S A 94 (2): 469–74.
(2) Ritter G., et al., 1997, Biochem Biophys Res Commun 236 (3): 682–6.