Human GM-CSF R alpha Protein, His Tag (SPR verified)

Source : 

Human GM-CSF R alpha, His Tag (SPR verified) (GRA-H52H7) is expressed from human 293 cells (HEK293). It contains AA Glu 23 - Gly 320 (Accession # P15509-1).

 

Molecule : GM-CSF R alpha

 

Synonyms : GM-CSF R alpha,GM-CSF-R-alpha,GMCSFR-alpha,GMR-alpha,CSF2RA,CSF2R,CSF2RY,CDw116,CD116

 

Format : Powder

 

Category : Other Recombinant Proteins

 

Accession : NP_006131.2

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 36.4 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 36.4 kDa. The protein migrates as 60-65 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : PBS, pH7.4

 

Description :

GM-CSF R alpha(Granulocyte-macrophage colony-stimulating factor receptor subunit alpha) is also known as CSF2RA, CD116, GMR-alpha. Low affinity receptor for granulocyte-macrophage colony-stimulating factor. Transduces a signal that results in the proliferation, differentiation, and functional activation of hematopoietic cells. Hereditary pulmonary alveolar proteinosis (hPAP) is a rare disorder of pulmonary surfactant accumulation and hypoxemic respiratory failure caused by mutations in CSF2RA (encoding the granulocyte/macrophage colony-stimulating factor [GM-CSF] receptor α-chain [CD116]), which results in reduced GM-CSF-dependent pulmonary surfactant clearance by alveolar macrophages.

 

References :

(1) Hetzel M, et al. 2017. Hum Gene Ther Methods. 28(6):318-329.
(2) Wang SL, et al. 2003, Sheng Li Xue Bao. 55(4):487-92.