Human Glypican 3 / GPC3 Protein, His Tag

Source : 

Human Glypican 3, His Tag (GP3-H52H4) is expressed from human 293 cells (HEK293). It contains AA Gln 25 - His 559 (Accession # P51654-1).

 

Molecule : Glypican 3

 

Synonyms : GPC3,OCI5,Glypican-3,GTR2-2,MXR7,DGSX,SDYS ,SGB,SGBS,SGBS1

 

Format : Powder

 

Category : Bio-Markers & CD Antigens

 

Accession : NP_004475.1

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 38.1 kDa and 24.6 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the C-terminus.
This protein contains a furin-like convertase cleavage site, 355-RQYR-358, and will be partially processed into N and C-terminal fragment with calculated MW of 38.1 kDa and 24.6 kDa respectively

 

Endotoxin Level : Less than 0.1 EU per μg by the LAL method.

 

Buffer : PBS, pH7.4

 

Description :

Glypican-3 (GPC3) is also known as Intestinal protein OCI-5, GTR2-2, MXR7, which belongs to the glypican family. Glypican 3 / GPC-3 is highly expressed in lung, liver and kidney. Glypican-3 inhibits the dipeptidyl peptidase activity of DPP4. Glypican-3 may be involved in the suppression/modulation of growth in the predominantly mesodermal tissues and organs, and also may play a role in the modulation of IGF2 interactions with its receptor and thereby modulate its function.

 

References :

(1) Davoodi J., et al., 2007, Proteomics 7:2300-2310.
(2) Veugelers M., et al., 2000, Hum. Mol. Genet. 9:1321-1328.