Human Glypican 2 / GPC2 Protein, Fc Tag

Source : 

Human Glypican 2, Fc Tag (GP2-H5255) is expressed from human 293 cells (HEK293). It contains AA Ser 24 - Ser 553 (Accession # Q8N158-1).

 

Molecule : Glypican 2

 

Synonyms : Glypican 2,GPC2

 

Format : Powder

 

Category : Bio-Markers & CD Antigens

 

Accession : NP_689955.1

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 37.3 kDa & 47.3 kDa

 

Characteristics :

This protein carries a human IgG1 Fc tag at the C-terminus.
This protein contains a furin cleavage site, 355-RNRR-358, and will be processed into N and C-terminal fragment with calculated MW of 37.3 kDa and 47.3 kDa respectively. The N and C‑terminal frag

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : Tris with Glycine, Arginine and NaCl, pH7.5

 

Description :

Glypican 2 (GPC2), also known cerebroglycan, is a glycophosphatidylinositol-linked integral membrane heparan sulfate proteoglycan found in the developing nervous system. Cerebroglycan participates in cell adhesion and is thought to regulate the growth and guidance of axons. Cerebroglycan has especially high affinity for laminin-1. GPC2 silencing inactivates Wnt/β-catenin signaling and reduces the expression of N-Myc, an oncogenic driver of neuroblastoma tumorigenesis. Immunotoxins and chimeric antigen receptor (CAR) T cells targeting GPC2 inhibit neuroblastoma growth in mouse models. A GPC3 specific antibody drug conjugate (ADC) can also inhibit neuroblastoma cell proliferation.

 

References :

(1) Herndon ME, et al. 1999. Glycobiology. 9(2):143-55.
(2) Li N, et al. 2017. Proc Natl Acad Sci U S A. 114(32):E6623-E6631.
(3) Bosse KR, et al. 2017. Cancer Cell. 32(3):295-309.