Human Glypican 1 / GPC1 Protein, Fc Tag

Source : 

Human Glypican 1, Fc Tag (GP1-H5254) is expressed from human 293 cells (HEK293). It contains AA Asp 24 - Ser 530 (Accession # P35052-1).

 

Molecule : Glypican 1

 

Synonyms : Glypican 1,GPC1

 

Format : Powder

 

Category : Bio-Markers & CD Antigens

 

Accession : NP_002072.2

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 82.5 kDa

 

Characteristics :

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 82.5 kDa. The protein migrates as 90 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : Tris with Glycine, Arginine and NaCl, pH7.5

 

Description :

Glypican 1 has been shown to interact with SLIT2. This protein is involved in the misfolding of normal prion proteins in the cell membrane to the infectious prion form. Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation.

 

References :

(1) Vermeesch JR, et al. 1995. Genomics. 25(1):327-9.
(2) Ronca F, et al. 2001. J Biol Chem. 276(31):29141-7.
(3) Taylor DR, et al. 2009. PLoS Pathog. 5(11):e1000666.