Human GFR alpha-like Protein, His Tag

Source : 

Human GFR alpha-like, His Tag (GFA-H52H3) is expressed from human 293 cells (HEK293). It contains AA Ser 19 - Glu 351 (Accession # Q6UXV0-1).

 

Molecule : GFR alpha-like

 

Synonyms : GFR alpha like,GFR alpha-like,GFRAL,GRAL

 

Format : Powder

 

Category : Other Recombinant Proteins

 

Accession : NP_997293.2

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 39.7 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 39.7 kDa. The protein migrates as 45-60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : PBS, pH7.4

 

Description :

GFR alpha-like is also known as GDNF family receptor alpha-like, GFRAL, C6orf144, UNQ9356, PRO34128. Growth differentiation factor-15 (GDF15) is a circulating protein that has been implicated in multiple biological processes, including energy homeostasis, body weight regulation, and cachexia driven by cancer and chronic disease. GDNF family receptor α-like (GFRAL) was recently identified as the neuronal brainstem receptor responsible for mediating the anorectic actions of GDF15. Brainstem-restricted receptor for GDF15 which regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses . Upon interaction with its ligand, GDF15, interacts with RET and induces cellular signaling through activation of MAPK- and AKT- signaling pathways.

 

References :

(1) Hsu JY, et al. 2017. Nature. 550(7675):255-259. (2) Mullican SE, et al. 2018. Trends Endocrinol Metab. 29(8):560-570. (3) Mullican SE, et al. 2017. Nat Med. 1150-1157.