Human Galectin-9 / LGALS9 Protein, His Tag

Source : 

Human Galectin-9, His Tag (LG9-H5244) is expressed from human 293 cells (HEK293). It contains AA Ala 2 - Thr 323 (Accession # BAA31542).

 

Molecule : Galectin-9

 

Synonyms : Galectin-9,LGALS9,Ecalectin

 

Format : Powder

 

Category : Immune Checkpoint Proteins

 

Accession : NP_002299

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 36.6 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 36.6 kDa. The protein migrates as 45-55 kDa under reducing (R) condition (SDS-PAGE).

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : 20 mM MOPS, 50 mM NaCl, 1 mM EDTA, 2 mM DTT, pH7.4

 

Description :

Galectin-9 (LGALS9) is also known as tumor antigen HOM-HD-21 and ecalectin. Galectins are a family of proteins defined by their binding specificity for β-galactoside sugars, such as N-acetyllactosamine (Galβ1-3GlcNAc or Galβ1-4GlcNAc), which can be bound to proteins by either N-linked or O-linked glycosylation. As for Galectin-9, it has high affinity for the Forssman pentasaccharide, and it is also the ligand for HAVCR2/TIM3. Forthermore, Galectin-9 stimulates bactericidal activity in infected macrophages by causing macrophage activation and IL1B secretion which restricts intracellular bacterial growth.

 

References :

(1) Tuereci O., et al., 1997, J. Biol. Chem. 272:6416-6422.
(2) Dai S.Y., et al.,2005, J. Immunol. 175:2974-2981.