Human Galectin-4 / LGALS4 / L36LBP Protein, His tag

Source : 

Human Galectin-4, His Tag (GA4-H5246) is expressed from human 293 cells (HEK293). It contains AA Met 1 - Ile 323 (Accession # P56470-1).

 

Molecule : Galectin-4

 

Synonyms : LGALS4,L36LBP,Gal-4,Antigen NY-CO-27,Lactose-binding lectin 4

 

Format : Powder

 

Category : Other Recombinant Proteins

 

Accession : NP_006140.1

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 38.1 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 38.1 kDa. The protein migrates as 40-44 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : 50 mM HEPES, 150 mM NaCl, 5 mM EDTA, 2 mM TCEP, pH7.4

 

Description :

Galectin-4 (Gal-4), also known as L36LBP (L-36 lactose-binding protein). The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. Galectin-4 expression is concentrated within microvilli in the gastrointestinal epithelium, where it can interact with CD3 and bind activated T cells in the lamina propria during intestinal inflammation. LGALS4 is an S-type lectin that is strongly underexpressed in colorectal cancer.

 

References :

(1) Barondes SH., et al., 1994, J. Biol. Chem. 269 (33): 20807-20810.
(2) Yang, RY., et al., 2008, Expert Rev. Mol. Med. 10: e17.
(3) Ideo H., et al., 2007, J. Biol. Chem. 282 (29): 21081-21089.