Human Frizzled-7 / FZD7 Protein, Fc Tag

Source : 

Human Frizzled-7, Fc Tag (FZ7-H5258) is expressed from human 293 cells (HEK293). It contains AA Gln 33 - Leu 185 (Accession # AAH15915).

 

Molecule : Frizzled-7

 

Synonyms : FZD7,Frizzled-7,FzE3,Fz-7,hFz7

 

Format : Powder

 

Category : Bio-Markers & CD Antigens

 

Accession : AAH15915

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 43.3 kDa

 

Characteristics :

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 43.3 kDa. The protein migrates as 50-55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : Tris with Glycine, Arginine and NaCl, pH7.5

 

Description :

Frizzled-7 (FZD7) is also known as FzE3, which belongs to the G-protein coupled receptor Fz/Smo family. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. FZD7 contains one FZ (frizzled) domain. FZD7 is receptor for Wnt proteins. FZD7 may be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. FZD7 interacts with MAGI3 and DVL1.

 

References :

(1) Sagara N., et al., 1998, Biochem. Biophys. Res. Commun. 252:117-122.