Human Frizzled-5 / FZD5 Protein, Fc Tag

Source : 

Human Frizzled-5, Fc Tag (FZ5-H5259) is expressed from human 293 cells (HEK293). It contains AA Ala 27 - Pro 167 (Accession # Q13467).

 

Molecule : Frizzled-5

 

Synonyms : FZD5,Frizzled-5,C2orf31,,Fz-5,hFz5,FzE5

 

Format : Powder

 

Category : Bio-Markers & CD Antigens

 

Accession : Q13467

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 42.6 kDa

 

Characteristics :

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 42.6 kDa. The protein migrates as 50-60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : PBS, pH7.4

 

Description :

Frizzled-5 (FZD5) is also known as FzE5, which belongs to the G-protein coupled receptor Fz/Smo family. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. FZD5 contains one FZ (frizzled) domain. FZD5 may be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. FZD5 interacts specifically with Wnt5A to induce the beta-catenin pathway. FZD5 interacts with GOPC.

 

References :

(1) Hsieh J.C., et al., 1999, Proc. Natl. Acad. Sci. U.S.A. 96:3546-3551.
(2) Hao H.X., et al., 2012, Nature 485:195-200.