Human Frizzled-4 / FZD4 Protein, Fc Tag

Source : 

Human Frizzled-4, Fc Tag (FZ4-H5250) is expressed from human 293 cells (HEK293). It contains AA Phe 37 - Glu 180 (Accession # AAI14528).

 

Molecule : Frizzled-4

 

Synonyms : FZD4,Frizzled-4,CD344,Fz-4,hFz4,FzE4

 

Format : Powder

 

Category : Bio-Markers & CD Antigens

 

Accession : AAI14528

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 42.9 kDa

 

Characteristics :

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 42.9 kDa. The protein migrates as 50-65 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : PBS, pH7.4

 

Description :

Frizzled-4 (FZD4) is also known as FzE4, CD344, which belongs to the G-protein coupled receptor Fz/Smo family. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. FZD4 contains one FZ (frizzled) domain. FZD4 may be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. FZD4 interacts with MAGI3 and norrin (NDP).

 

References :

(1) Nallathambi J., et al., 2006, Mol. Vis. 12:1086-1092.
(2) Sjoeblom T., et al., 2006, Science 314:268-274.