Human Frizzled-2 / FZD2 Protein, Fc Tag

Source : 

Human Frizzled-2, Fc Tag (FZ2-H5251) is expressed from human 293 cells (HEK293). It contains AA Gln 24 - Ser 156 (Accession # AAI13403).

 

Molecule : Frizzled-2

 

Synonyms : FZD2,Frizzled-2,Fz-2,hFz2,FzE2

 

Format : Powder

 

Category : Bio-Markers & CD Antigens

 

Accession : AAI13403

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 41.7 kDa

 

Characteristics :

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 41.7 kDa. The protein migrates as 50-55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : Tris with Glycine, Arginine and NaCl, pH7.5

 

Description :

Frizzled-2 (FZD2) is also known as FzE2, which belongs to the G-protein coupled receptor Fz/Smo family. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. FZD2 contains one FZ (frizzled) domain. FZD2 may be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. The Lys-Thr-X-X-X-Trp motif of FZD2 interacts with the PDZ doman of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway.

 

References :

(1) Sagara N., et al., 1998, Biochem. Biophys. Res. Commun. 252:117-122.