Human FKBP4 / FKBP52 Protein, His,PA Tag

Source : 

Human FKBP4, His,PA Tag (FK4-H52Q3) is expressed from human 293 cells (HEK293). It contains AA Met 1 - Ala 459 (Accession # AAH01786).

 

Molecule : FKBP4

 

Synonyms : FKBP4,FKBP52

 

Format : Powder

 

Category : Other Recombinant Proteins

 

Accession : AAH01786

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 55.1 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the C-terminus, followed by a PA tag, and has a calculated MW of 55.1 kDa. The reducing (R) protein migrates as 60 kDa in SDS-PAGE.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : 50 mM Tris, 100 mM Glycine, pH7.5

 

Description :

Peptidyl-prolyl cis-trans isomerase FKBP4 (PPIase FKBP4) is also known as immunophilin FKBP52. FKBP4 is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. FKBP4 has high structural and functional similarity to FK506-binding protein 1A (FKBP1A), but unlike FKBP1A, this protein does not have immunosuppressant activity when complexed with FK506. FKBP4 interacts with interferon regulatory factor-4 and plays an important role in immunoregulatory gene expression in B and T lymphocytes.

 

References :

(1) Tai P.-K.K., et at., 1992, Science 256:1315-1318.
(2) Shim S., et al., 2009, Neuron 64:471-483.