Human Fetuin A / FETUA Protein, His Tag

Source : 

Human Fetuin A, His Tag (FEA-H5221) is expressed from human 293 cells (HEK293). It contains AA Ala 19 - Val 367 (Accession # P02765-1).

 

Molecule : Fetuin A

 

Synonyms : AHSG,FETUA,Fetuin A

 

Format : Powder

 

Category : Other Recombinant Proteins

 

Accession : NP_001613.2

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 38.2 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 38.2 kDa. The protein migrates as 45-55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : PBS, pH7.4

 

Description :

Alpha-2-HS-glycoprotein (AHSG) is also known as Alpha-2-Z-globulin, Ba-alpha-2-glycoprotein, Fetuin-A (FETUA), is a glycoprotein that is composed of two subunits, the A and B chains, belongs to the cystatin family of proteases inhibitors and the fetuin class of plasma binding proteins. AHSG / Fetuin A is highly expressed in embryonic cells and adult hepatocytes, and is expressed to a lesser extent in monocytes/macrophages. Fetuins are carrier proteins like albumin. Fetuin-A / AHSG forms soluble complexes with calcium and phosphate and thus is a carrier of otherwise insoluble calcium phosphate. Thus AHSG / Fetuin A is a potent inhibitor of pathological calcification. Fetuin A / FETUA promotes phagocytosis of apoptotic cells and plays a role in bone development, calcium homeostasis and insulin sensitivity. Mice deficient in Fetuin-A show systemic calcification of soft tissues.

 

References :

(1) Jahnen-Dechent W., et al., 1994, Eur. J. Biochem. 226 (1): 59–69.
(2) Lee C., et al., 2009, Frontiers in Bioscience 14: 2911–2922.
(3) Heiss A., et al., 2008, J. Biol. Chem. 283 (21): 14815–25.
(4) Jahnen-Dechent W., et al., 2008, J. Mol. Med. 86 (4): 379–89.