Human Fc epsilon RI alpha Protein, Fc Tag (BLI verified)

Source : 

Human Fc epsilon RI alpha, Fc Tag (BLI verified) (FCA-H5259) is expressed from human 293 cells (HEK293). It contains AA Val 26 - Leu 204 (Accession # P12319-1).

 

Molecule : Fc epsilon RI alpha

 

Synonyms : FCER1A,FCE1A,FcERI

 

Format : Powder

 

Category : Bio-Markers & CD Antigens

 

Accession : NP_001992.1

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 47.3 kDa

 

Characteristics :

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 47.3 kDa. The protein migrates as 55-85 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : Tris with Glycine, Arginine and NaCl, pH7.5

 

Description :

High affinity immunoglobulin epsilon receptor subunit alpha (FCER1A) is also known as Fc-epsilon RI-alpha (FcERI), IgE Fc receptor subunit alpha, FCE1A. FCER1A contains two Ig-like (immunoglobulin-like) domains. FCER1A binds to the Fc region of immunoglobulins epsilon and is a high affinity receptor. FCER1A is responsible for initiating the allergic response, which binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators (such as histamine) responsible for the manifestations of allergy. The same receptor also induces the secretion of important lymphokines. FCER1A plays a central role in allergic disease, coupling allergen and mast cell to initiate the inflammatory and immediate hypersensitivity responses that are characteristic of disorders such as hay fever and asthma.

 

References :

(1) Yagi S., et al., 1994, Eur. J. Biochem. 220:593-598.
(2) Garman S.C., et al., 1998, Cell 95:951-961.
(3) Garman S.C., et al., 2001, J. Mol. Biol. 311:1049-1062.