Human FABP6 Protein, His Tag

Source : 

Human FABP6, His Tag (FA6-H5141) is expressed from E.coli cells. It contains AA Ala 2 - Ala 128 (Accession # AAH22489).

 

Molecule : FABP6

 

Synonyms : FABP6,ILBP,ILLBP,Gastrotropin,GT,I-15P,I-BABP,I-BALB,I-BAP

 

Format : Powder

 

Category : Bio-Markers & CD Antigens

 

Accession : AAH22489

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 15.3 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 15.3 kDa. The protein migrates as 15 kDa under reducing (R) condition (SDS-PAGE).

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : PBS, pH7.4

 

Description :

Fatty acid-binding protein 6 (FABP6), is also known as Intestinal bile acid-binding protein (I-BABP), Ileal lipid-binding protein (ILBP), Intestinal 15 kDa protein (I-15P), Gastrotropin (GT). FABP6 is a cytoplasm protein which belongs to the calycin superfamily and fatty-acid binding protein (FABP) family. Isoform 2 of FABP6 is expressed in colorectal adenocarcinomas and their adjacent normal mucosa (at protein level). Isoform 1 of FABP6 is expressed in the jejunum, ileum, cecum and ascending colon intestine. Ileal protein FABP6 stimulates gastric acid and pepsinogen secretion. FABP6 seems to be able to bind to bile salts and bilirubins. Isoform 2 of FABP6 is essential for the survival of colon cancer cells to bile acid-induced apoptosis.

 

References :

(1) Fujita M., et al., 1995, Eur. J. Biochem. 233:406-413.
(2) Fang C., et al., 2007, Cancer Res. 67:9039-9046.