Human Ephrin-A4 / EFNA4 Protein, Fc Tag

Source : 

Human Ephrin-A4, Fc Tag (EA4-H5250) is expressed from human 293 cells (HEK293). It contains AA Leu 26 - Gly 171 (Accession # AAI07484).

 

Molecule : Ephrin-A4

 

Synonyms : EFNA4,EPLG4,LERK4,Ephrin-A4

 

Format : Powder

 

Category : Bio-Markers & CD Antigens

 

Accession : AAI07484

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 43.0 kDa

 

Characteristics :

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 43.0 kDa. The protein migrates as 34 kDa and 48 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : Tris with Glycine, Arginine and NaCl, pH7.5

 

Description :

Ephrin-A4 (EFNA4) is also known as EPH-related receptor tyrosine kinase ligand 4 (LERK4), EPLG4, which belongs to the ephrin family. EFNA4 contains one ephrin RBD (ephrin receptor-binding) domain. EFNA4 is cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. EFNA4 binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. EFNA4 may play a role in the interaction between activated B-lymphocytes and dendritic cells in tonsils.

 

References :

(1) Aasheim H.-C., et al., 2000, Blood 95:221-230.
(2) Kozlosky C.J., et al., 1995, Oncogene 10:299-306.