Human Ephrin-A3 / EFNA3 Protein, Fc Tag

Source : 

Human Ephrin-A3, Fc Tag (EA3-H5258) is expressed from human 293 cells (HEK293). It contains AA Gln 23 - Ser 213 (Accession # AAI10407).

 

Molecule : Ephrin-A3

 

Synonyms : Ephrin-A3,EFL-2,EHK1-L,LERK-3,EFNA3

 

Format : Powder

 

Category : Bio-Markers & CD Antigens

 

Accession : AAI10407

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 48 kDa

 

Characteristics :

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 48 kDa. The protein migrates as 57-65 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : Tris with Glycine, Arginine and NaCl, pH7.5

 

Description :

Ephrin-A3 (Ephrin A3) is also known as EFL-2, EHK1 ligand, EHK1-L, EPH-related receptor tyrosine kinase ligand 3, EFL2, EPLG3 and LERK3,which comprises the largest subfamily of receptor protein-tyrosine kinases (RTKs), and has been involved in a variety of biological processes, especially in the nervous system and in erythropoiesis, such as axon guidance and topographic map formation, synaptic plasticity, angiogenesis, and meanwhile have possible contributions to tumor growth and metastasis. Ephrin A3 is cell surface GPI-bound ligand for Eph receptors and belongs to the family of receptor tyrosine kinases. Ephrin can bind promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells.

 

References :

(1) Kozlosky C.J. et al., 1995, Oncogene 10:299-306.
(2) Davis S., et al., 1994, Science 266:816-819.