Human Ephrin-A1 / EFNA1 Protein, Fc Tag

Source : 

Human Ephrin-A1, Fc Tag (EF1-H5251) is expressed from human 293 cells (HEK293). It contains AA Asp 19 - Ser 182 (Accession # P20827-1).

 

Molecule : Ephrin-A1

 

Synonyms : EFNA1,Ephrin-A1,LERK-1,TNFAIP4,EPLG1,B61,ECKLG,EFL1

 

Format : Powder

 

Category : Bio-Markers & CD Antigens

 

Accession : NP_004419.2

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 46.0 kDa

 

Characteristics :

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 46.0 kDa. As a result of glycosylation, the protein migrates as 53-57 kDa under reducing (R) condition, and 100-115 kDa under non-reducing (NR) condition (SDS-P

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : 50 mM Tris, 100 mM Glycine, pH7.5

 

Description :

Ephrin-A1 (EFNA1) is also known as EPLG1, LERK1, TNFAIP4, Immediate early response protein B61, which belongs to the ephrin family. EFNA1 contains one ephrin RBD (ephrin receptor-binding) domain. EFNA1 is cell surface GPI-bound ligand for Eph receptors, and is a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. EFNA1 binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. EFNA1 plays an important role in angiogenesis and tumor neovascularization.

 

References :

(1) Liu D.-P., et al., 2007, Int. J. Oncol. 30:865-871.
(2) Wykosky J., et al., 2008, Oncogene 27:7260-7273.