Human EGF R Protein, Strep Tag

Source : 

Human EGF R, Strep Tag (EGR-H5285) is expressed from human 293 cells (HEK293). It contains AA Leu 25 - Ser 645 (Accession # NP_005219.2).

 

Molecule : EGF R

 

Synonyms : EGFR,ERBB,ERBB1,HER1,PIG61,mENA

 

Format : Powder

 

Category : Bio-Markers & CD Antigens

 

Accession : NP_005219.2

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 71.6 kDa

 

Characteristics :

This protein carries a twin strep tag at the C-terminus. The protein has a calculated MW of 71.6 kDa. The protein migrates as 110-115 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : PBS, pH7.4

 

Description :

The epidermal growth factor receptor (EGFR; ErbB-1; HER1 in humans) is the cell-surface receptor for members of the epidermal growth factor family (EGF-family) of extracellular protein ligands. The epidermal growth factor receptor is a member of the ErbB family of receptors, a subfamily of four closely related receptor tyrosine kinases: EGFR (ErbB-1), HER2/c-neu (ErbB-2), Her 3 (ErbB-3) and Her 4 (ErbB-4). Mutations affecting EGFR expression or activity could result in cancer.

 

References :

(1) Herbst RS., 2004, Int. J. Radiat. Oncol. Biol. Phys. 59 (2 Suppl): 21–6.
(2) Giaccone, G., 2005, Ann. Onc. 16: 538-548.