Human E-Cadherin / Cadherin-1 Protein, Fc Tag

Source : 

Human E-Cadherin, Fc Tag (ECD-H5250) is expressed from human 293 cells (HEK293). It contains AA Gln 23 - Pro 621 (Accession # AAI41839).

 

Molecule : E-Cadherin

 

Synonyms : Cadherin-1,CDH1,CD324,E-cadherin,Arc-1,ECAD,LCAM,UVO

 

Format : Powder

 

Category : Bio-Markers & CD Antigens

 

Accession : AAI41839

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 92.3 kDa

 

Characteristics :

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 92.3 kDa. The protein migrates as 100 kDa and 120 kDa Cadherin, a 48 kDa Propeptide under reducing (R) condition (SDS-PAGE) due to different glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : 50 mM Tris, 100 mM Glycine, pH7.5

 

Description :

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Cadherin-1 (CDH1) is also known as epithelial cadherin (E-cadherin), CD_antigen (CD324), Uvomorulin (UVO) ECAD and CDHE, CDH1 / CD324 contains 5 cadherin domains. CDH1 / CD324 / ECAD is expressed in non-neural epithelial tissues. CDH1 / E-CAD is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells and has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7. E-Cad promotes non-amyloidogenic degradation of Abeta precursors and has a strong inhibitory effect on APP C99 and C83 production. Defects in CDH1 / CD324 / ECAD are the cause of hereditary diffuse gastric cancer (HDGC).

 

References :

(1) Agiostratidou G., et al., 2006, J. Neurochem. 96:1182-1188.
(2) Meng Y.G., et al., 2007, Cell Res. 17:869-880.
(3) Yoon K.-A., et al., 1999, J. Hum. Genet. 44:177-180.