Human DR6 / TNFRSF21 Protein, Fc Tag

Source : 

Human DR6, Fc Tag (TN1-H5252) is expressed from human 293 cells (HEK293). It contains AA Gln 42 - Leu 350 (Accession # AAH17730).

 

Molecule : DR6

 

Synonyms : TNFRSF21,DR6,CD358,BM-018

 

Format : Powder

 

Category : Bio-Markers & CD Antigens

 

Accession : AAH17730

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 60.2 kDa

 

Characteristics :

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 60.2 kDa. The protein migrates as 80-95kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : 50 mM Tris, 100 mM Glycine, pH7.5

 

Description :

Tumor necrosis factor receptor superfamily member 21 (TNFRSF21) is also known as death receptor 6 (DR6), which is a member of the TNF-receptor superfamily. TNFRSF21 contains one death domain and four TNFR-Cys repeats. TNFRSF21 / DR6 has been shown to activate NF-κB and MAPK8/JNK, and induce cell apoptosis. Through its death domain, this receptor interacts with TRADD protein, which is known to serve as an adaptor that mediates signal transduction of TNF-receptors.

 

References :

(1) Pan G., et al., 1998, FEBS Lett. 431 (3): 351–356.
(2) Kuester M., et al., 2011, J. Mol. Biol. 409 (2): 189–201.