Human DLL4 Protein, His Tag

Source : 

Human DLL4, His Tag (DL4-H5227) is expressed from human 293 cells (HEK293). It contains AA Ser 27 - Pro 524 (Accession # Q9NR61-1).

 

Molecule : DLL4

 

Synonyms : DLL4,Delta4

 

Format : Powder

 

Category : Bio-Markers & CD Antigens

 

Accession : AAI06951

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 55.5 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 55.5 kDa. The protein migrates as 58-70 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : PBS, pH7.4

 

Description :

Delta-like protein 4 (DLL4) is also known as Drosophila Delta homolog 4 (Delta4), which contains one DSL domain and eight EGF-like domains. DLL4 is expressed in vascular endothelium. DLL4 is involved in the Notch signaling pathway as Notch ligand, which can activates NOTCH1 and NOTCH4. DLL4 is involved in angiogenesis and negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. DLL4 can bind to Notch-1 and Notch-4.

 

References :

(1) Del Barrio M.G., et al., 2007, Development 134:3427-3436.
(2) Brutsch R., et al., 2010, Circ. Res. 107:592-601.